diff --git a/htslib-1.21.tar.bz2 b/htslib-1.22.1.tar.bz2
similarity index 39%
rename from htslib-1.21.tar.bz2
rename to htslib-1.22.1.tar.bz2
index 7e75bc4d74548acc5b698a1a8150268737cf55c2..730b40ee611691aced8740f9e1976cdfe8799099 100644
Binary files a/htslib-1.21.tar.bz2 and b/htslib-1.22.1.tar.bz2 differ
diff --git a/htslib.spec b/htslib.spec
index 05dea7ed41c72c81a553625dfe408afbf0d23030..c4fb026509c8b780e679aaea52faae121ef79386 100644
--- a/htslib.spec
+++ b/htslib.spec
@@ -1,5 +1,5 @@
 Name:    htslib
-Version: 1.21
+Version: 1.22.1
 Release: 1
 Summary: C library for high-throughput sequencing data formats
 License: MIT and BSD
@@ -77,12 +77,17 @@ rm -rf %{buildroot}/%{_libdir}/libhts.a
 %{_bindir}/htsfile
 %{_bindir}/tabix
 %{_bindir}/annot-tsv
+%{_bindir}/ref-cache
 %{_mandir}/man1/annot-tsv.1*
 %{_mandir}/man1/bgzip.1*
 %{_mandir}/man1/htsfile.1*
 %{_mandir}/man1/tabix.1*
+%{_mandir}/man1/ref-cache.1*
 
 %changelog
+* Sun Sep 28 2025 maqi <maqi@uniontech.com> - 1.22.1-1
+- Update to 1.22.1
+
 * Fri Nov 22 2024 wangxiaomeng <wangxiaomeng@kylinos.cn> - 1.21-1
 - Update to 1.21